September Monthly Meeting

Spectroscopy Society of Pittsburgh Monthly Meeting

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WHEN: Wednesday – September 16
RSVP BY: Thursday – September 9 – by NOON

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Technology Forum Speaker’s Presentation & Social Hour: 5:30 PM – Power Center Ballroom Section C
Social Hour: 5:30 PM – Power Center Fides Shepperson Suite
Dinner: 6:30 PM – Power Center Ballroom Section C
Business Meeting: 8:00 PM – Power Center Ballroom Section C
Technical Program Speaker’s Presentation: 8:15 PM – Power Center Ballroom Section C

TECHNICAL FORUM – 5:30 PM
Ronald A. Schwartz , Assistant Regional Director – PA Department of Environmental Protection, Southwest Region

“Permitting a Major Industrial Facility in SW PA”
Hear the fascinating story of what goes in to permitting a major industrial facility in our region.

…Read Bio


TECHNOLOGY PROGRAM – 8:15 PM
Rafael P. Bruschweiler, Ohio State University Dept. of Chemistry & Biochemistry and Dept. of Biological Chemistry and Pharmacology

“Multi-dimensional NMR and NMR/MS Hybrid Approaches for Metabolomics”
The field of metabolomics has become a key discipline to study metabolism of living organisms, including biofluids and tissue samples, in a wide range of contexts, including health and disease. Most metabolomics studies seek information about both the identity and the quantity of dozens to hundreds of different metabolites present in a biological sample. The two main analytical techniques in metabolomics are nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS), which both allow the detection of many different metabolites directly in complex mixtures with little or no prior purification. I will discuss recent progress using 2D NMR, which includes the development of customized NMR databases and de novo approaches for the reconstruction of molecular structures of unknown metabolites. Both NMR and MS are successful methods in their own right, but only very few applications make synergistic use of the complementary information they provide. We recently developed two new methods, which combine NMR and MS for the more accurate identification of catalogued metabolites by translating the NMR information into masses (‘NMR/MS translator’) and for the determination of the structures of unknown metabolites by translating accurate mass information into NMR spectra (‘SUMMIT approach’). These methods will be explained and demonstrated for different types of samples and applications. …Read Bio